| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Instrumentação. |
|
Data corrente: |
08/06/2021 |
|
Data da última atualização: |
10/06/2022 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
FACCHINATTO, W. M.; GALANTE, J.; MESQUITA, L.; SILVA, D. S.; SANTOS, D. M. dos; MORAES, T. B.; CAMPANA-FILHO, S. P.; COLNAGO, L. A.; SARMENTO, B.; NEVES, J. das. |
|
Afiliação: |
LUIZ ALBERTO COLNAGO, CNPDIA. |
|
Título: |
Clotrimazole-loaded N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles for topical treatment of vulvovaginal candidiasis. |
|
Ano de publicação: |
2021 |
|
Fonte/Imprenta: |
Acta Biomaterialia, v. 125, 2021. |
|
Páginas: |
312?321 |
|
ISSN: |
172-7061 |
|
DOI: |
https://doi.org/10.1016/j.actbio.2021.02.029 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Vulvovaginal candidiasis (VVC) represents a considerable health burden for women. Despite the availability of a significant array of antifungal drugs and topical products, the management of the infection is not always effective, and new approaches are needed. Here, we explored cationic N-(2-hydroxy)- propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles (NPs) as carriers of clotrimazole (CLT) for the topical treatment of VVC. CLT-NPs with approximately 280 nm in diameter were obtained by selfassembly in water and subsequent stabilization by ionic crosslinking with tripolyphosphate. The nanosystem featured pH-independent sustained drug release up to 24 h, which affected both in vitro anti-Candida activity and cytotoxicity. The CLT-loaded nanostructured platform yielded favorable selectivity index values for a panel of standard strains and clinical isolates of Candida spp. and female genital tract cell lines (HEC-1-A, Ca Ski and HeLa), as compared to the free drug. CLT-NPs also improved in vitro drug permeability across HEC-1-A and Ca Ski cell monolayers, thus suggesting that the nanocarrier may provide higher mucosal tissue levels of the active compound. Overall, data support that CLT-NPs may be a valuable asset for the topical treatment of VVC. |
|
Palavras-Chave: |
Health; Vaginal drug delivery; Women s health. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 02189naa a2200301 a 4500
001 2132239
005 2022-06-10
008 2021 bl uuuu u00u1 u #d
022 $a172-7061
024 7 $ahttps://doi.org/10.1016/j.actbio.2021.02.029$2DOI
100 1 $aFACCHINATTO, W. M.
245 $aClotrimazole-loaded N-(2-hydroxy)-propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles for topical treatment of vulvovaginal candidiasis.$h[electronic resource]
260 $c2021
300 $a312?321
520 $aVulvovaginal candidiasis (VVC) represents a considerable health burden for women. Despite the availability of a significant array of antifungal drugs and topical products, the management of the infection is not always effective, and new approaches are needed. Here, we explored cationic N-(2-hydroxy)- propyl-3-trimethylammonium, O-palmitoyl chitosan nanoparticles (NPs) as carriers of clotrimazole (CLT) for the topical treatment of VVC. CLT-NPs with approximately 280 nm in diameter were obtained by selfassembly in water and subsequent stabilization by ionic crosslinking with tripolyphosphate. The nanosystem featured pH-independent sustained drug release up to 24 h, which affected both in vitro anti-Candida activity and cytotoxicity. The CLT-loaded nanostructured platform yielded favorable selectivity index values for a panel of standard strains and clinical isolates of Candida spp. and female genital tract cell lines (HEC-1-A, Ca Ski and HeLa), as compared to the free drug. CLT-NPs also improved in vitro drug permeability across HEC-1-A and Ca Ski cell monolayers, thus suggesting that the nanocarrier may provide higher mucosal tissue levels of the active compound. Overall, data support that CLT-NPs may be a valuable asset for the topical treatment of VVC.
653 $aHealth
653 $aVaginal drug delivery
653 $aWomen s health
700 1 $aGALANTE, J.
700 1 $aMESQUITA, L.
700 1 $aSILVA, D. S.
700 1 $aSANTOS, D. M. dos
700 1 $aMORAES, T. B.
700 1 $aCAMPANA-FILHO, S. P.
700 1 $aCOLNAGO, L. A.
700 1 $aSARMENTO, B.
700 1 $aNEVES, J. das
773 $tActa Biomaterialia$gv. 125, 2021.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Instrumentação (CNPDIA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
Registro Completo
|
Biblioteca(s): |
Embrapa Agropecuária Oeste; Embrapa Algodão; Embrapa Meio-Norte; Embrapa Rondônia. |
|
Data corrente: |
01/10/2010 |
|
Data da última atualização: |
20/07/2022 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Circulação/Nível: |
B - 1 |
|
Autoria: |
MORELLO, C. de L.; SUASSUNA, N. D.; FARIAS, F. J. C.; LAMAS, F. M.; PEDROSA, M. B.; RIBEIRO, J. L.; GODINHO, V. de P. C.; FREIRE, E. C. |
|
Afiliação: |
CAMILO DE LELIS MORELLO, CNPA; NELSON DIAS SUASSUNA, CNPA; FRANCISCO JOSE CORREIA FARIAS, CNPA; FERNANDO MENDES LAMAS, CPAO; MURILO BARROS PEDROSA, Fundação BA; JOSE LOPES RIBEIRO, CPAMN; VICENTE DE PAULO CAMPOS GODINHO, CPAF-RO; ELEUSIO CURVELO FREIRE, Cotton Consultoria. |
|
Título: |
BRS 293: A midseason high-yielding upland cotton cultivar for Brazilian savanna. |
|
Ano de publicação: |
2010 |
|
Fonte/Imprenta: |
Crop Breeding and Applied Biotechnology, Londrina, v. 10, n. 2, p. 180-182, June 2010. |
|
Idioma: |
Inglês |
|
Notas: |
Cultivar release. |
|
Conteúdo: |
Cotton cultivar BRS 293 is a midseason high-yield cultivar and has wide adaptation to the Brazilian savanna, yield stability, desirable resistance to main cotton diseases and good fiber quality. The cultivar BRS 293 meets growers' demands for competitive lint yield as well as fulfilling industrial textile requirements. |
|
Palavras-Chave: |
Cultivar; Cultivar de algodoeiro; Linter yield. |
|
Thesagro: |
Algodão; Gossypium Hirsutum; Variedade. |
|
Thesaurus NAL: |
Disease resistance. |
|
Categoria do assunto: |
--
G Melhoramento Genético |
|
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/27332/1/brs0001.pdf
|
|
Marc: |
LEADER 01185naa a2200301 a 4500
001 2144234
005 2022-07-20
008 2010 bl uuuu u00u1 u #d
100 1 $aMORELLO, C. de L.
245 $aBRS 293$bA midseason high-yielding upland cotton cultivar for Brazilian savanna.
260 $c2010
500 $aCultivar release.
520 $aCotton cultivar BRS 293 is a midseason high-yield cultivar and has wide adaptation to the Brazilian savanna, yield stability, desirable resistance to main cotton diseases and good fiber quality. The cultivar BRS 293 meets growers' demands for competitive lint yield as well as fulfilling industrial textile requirements.
650 $aDisease resistance
650 $aAlgodão
650 $aGossypium Hirsutum
650 $aVariedade
653 $aCultivar
653 $aCultivar de algodoeiro
653 $aLinter yield
700 1 $aSUASSUNA, N. D.
700 1 $aFARIAS, F. J. C.
700 1 $aLAMAS, F. M.
700 1 $aPEDROSA, M. B.
700 1 $aRIBEIRO, J. L.
700 1 $aGODINHO, V. de P. C.
700 1 $aFREIRE, E. C.
773 $tCrop Breeding and Applied Biotechnology, Londrina$gv. 10, n. 2, p. 180-182, June 2010.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Algodão (CNPA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
